Abstract #4155
Impact of B1 field inhomogeneity on DESPOT-based T1 and T2 mapping at 1.5T
Yulia Shcherbakova 1 , Cornelis A.T. van den Berg 1 , Jan J.W. Lagendijk 2 , Chrit T.W. Moonen 2 , and Lambertus W. Bartels 1
1
Imaging Division, University Medical Center,
Utrecht, Utrecht, Netherlands,
2
Imaging
Division, University Medical Center, Utrecht,
Netherlands
Rapid quantitative imaging is very important for
planning and guidance of MRI-guided oncological therapy.
The normal liver tissue and metastases have different T1
and T2 relaxation times and their ratio T1/T2 , which
makes these parameters relevant quantitative imaging
biomarkers. Conventional T1 and T2 mapping techniques
are relatively time-consuming, which has led to the
development of promising rapid techniques, such as
DESPOT1 and DESPOT2. However, in practice, even at 1.5T,
electromagnetic fields are imperfect, which may
influence the accuracy and precision of quantitative
imaging techniques. In this study we have investigated
the impact of B1 field inhomogeneity on the performance
of 3D DESPOT1 and DESPOT2 methods and demonstrated that
DESPOT1 method is sensitive to B1 field inhomogeneity,
even at 1.5T. A 5% error in nominal flip angle
significantly influences the calculated T1 value and
leads to a 10% error in the observed T1 value. However,
the T2 estimates are minimally affected, when T2 is
calculated using non-B1 corrected T1 values. Thus, the
influence of B1 deviations on T2 mapping is negligible,
so, B1 field correction for T2 mapping based on DESPOT2
method, is not required.
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