Abstract #4148
Multinuclear ( 19 F + 1 H) MRI at 3T using an internal probe
Shashank Sathyanarayana Hegde 1 , Li Pan 2 , Guan Wang 1,3 , Martin Radvany 1 , Yingli Fu 1 , and Dara L Kraitchman 1
1
Radiology, Johns Hopkins University,
Baltimore, Maryland, United States,
2
Siemens
Healthcare, Baltimore, Maryland, United States,
3
Electrical
and Computer Engineering, Johns Hopkins University,
Maryland, United States
We developed and characterized an internal probe at 3T
designed for interchangeable
1
H
and
19
F
use. The internal probe demonstrated increased
signal-to-noise ratio with respect to a conventional
19
F
surface coil for structures deeper than 2 cm from the
surface.
19
F
imaging of ~7.5mL of a 10-fold dilution (e.g., 5 mg/ml)
of fluorouracil (5-FU) was possible in 2 minutes.
Multinuclear MRI of perfluorooctyl bromide (PFOB)
microcapsules was performed in tissue samples ex vivo
and a rabbit thigh in vivo. High-resolution (0.2 mm
1
H
and 0.8 mm
19
F
in-plane) MRI of PFOB capsules was possible and was
concordant with cone beam computed tomography (CT)
imaging of the radiopaque microcapsules.
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