Abstract #4129
Experimental stress constricts small bowel and increases ascending colon volume in healthy subjects
Susan E Pritchard 1 , Klara C Garsed 2 , Caroline L Hoad 1 , Melanie Lingaya 3 , R Banwait 3 , W Thongborisute 3 , E Roberts 3 , Carolyn Costigan 1,3 , Luca Marciani 2,3 , Robin C Spiller 2,3 , and Penny A Gowland 1
1
Sir Peter Mansfield Imaging Centre,
University of Nottingham, Nottingham, Notts, United
Kingdom,
2
Nottingham
Digestive Diseases Biomedical Research Unit, Nottingham
University Hospitals, Nottingham, Notts, United Kingdom,
3
Nottingham
Digestive Diseases Centre, School of Clinical Sciences,
University of Nottingham, Nottingham, Notts, United
Kingdom
Stress is known to affect oro-caecal transit in patients
with irritable bowel syndrome with diarrhoea (IBS-D).
This study evaluated the effect of a sensory (ice-cold
versus warm water hand immersion) and a pharmaceutical
stressor (corticotrophin releasing hormone (CRH) versus
placebo) on postprandial fluid transport in the small
and large bowel in two groups of healthy volunteers.
Both stressors redistributed fluid in the intestine,
similar to that previously seen in IBS-D, and CRH also
increased the ascending colon volume. This was
associated with increased sensations of distension and
bloating. Similar mechanisms could account for symptoms
reported in IBS patients.
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