Abstract #4124
Non-invasive longitudinal study of an MRI biomarker for the quantification of colon inflammation in a mouse model of colitis
Andrea Bianchi 1 , Teresa Bluhmki 1 , Tanja Schoenberger 2 , Andrea Vgtle 1 , David Kind 1 , Eric Kaaru 1 , Michael Neumaier 1 , Birgit Stierstorfer 2 , Thomas Kaulisch 1 , and Detlef Stiller 1
1
Targeting Discovery Research, In vivo
imaging laboratory, Boehringer Ingelheim Pharma GmbH &
Co. KG, Biberach an der Riss, Baden-Wrttemberg,
Germany,
2
Targeting
Discovery Research, Target Validation Technologies,
Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an
der Riss, Baden-Wrttemberg, Germany
Colonoscopy, the current gold-standard for inflammatory
bowel disease diagnostics and follow-up, is known to
cause discomfort in patients. In addition, this
technique doesnt permit to detect extracolonic lesions,
being restricted to the diagnostics of visible changes
in the mucosal surface. We propose here an in vivo MRI
longitudinal study of colon wall thickness as an imaging
biomarker to detect and stage the severity of this
disease in a mouse model of dextran sulfate sodium
(DSS)-induced colitis. The results were validated
against colonoscopy and standard ex vivo histology. The
intra- and inter- operator reproducibility was assessed
for all the measurements.
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