Abstract #4122
Metabolic Adaptations Induced by Medium Chain Triglycerides in a Rat model of Diabetes Measured by in vivo Magnetic Resonance Spectroscopy
Lihong Jiang 1 , Zejian Liu 2 , Bei Wang 1 , Greame Mason 1,3 , Douglas Rothman 1 , and Raimund Herzog 2
1
Diagnostic Radiology, Yale University School
of Medicine, New Haven, CT, United States,
2
Internal
Medicine, Yale University School of Medicine, New Haven,
CT, United States,
3
Psychiatry,
Yale University School of Medicine, New Haven, CT,
United States
Medium chain triglycerides (MCTs) have been used for
treating food absorption disorders and digestive
diseases, and have been shown increase glucose
sensitivity in diabetic patients. We have investigated
the metabolic adaptations in STZ-treated diabetic rats
fed with a MCT-enriched diet, using
in
vivo
magnetic resonance spectroscopy and metabolic
modeling with infusions of [2,4-
13
C
2
]
-hydroxyl-butyrate
(BHB) under a hyperinsulinemic hypoglycemic clamp. We
have found that MCT diet decreased BHB uptake in
astrocytes and increased glucose oxidation in neurons.
The results were confirmed with qPCR technique. Our
results suggest that MCT diet may not help to increase
brain energy supply under acute hypoglycemia without
antecedent recurrent hypoglycemia.
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