Abstract #4113
Mapping Murine Diabetic Nephropathy: QMT, CEST and Fat Imaging
Feng Wang 1,2 , Ke Li 1,2 , Keiko Takahashi 3,4 , E. Brian Welch 1,2 , Zhongliang Zu 1,2 , Daniel Gochberg 1,2 , Raymond C. Harris 3,4 , C. Chad Quarles 1,2 , Takamune Takahashi 3,4 , and John C. Gore 1,2
1
Radiology and Radiological Sciences,
Vanderbilt University, Nashville, TN, United States,
2
Institute
of Imaging Sciences, Vanderbilt University, Nashville,
TN, United States,
3
Vanderbilt
O'Brien Mouse Kidney Physiology and Disease Center,
Vanderbilt University, TN, United States,
4
Division
of Nephrology and Hypertension, Vanderbilt University,
TN, United States
Diabetic nephropathy (DN) is the leading cause of renal
failure. Murine models of DN are routinely used to
evaluate the mechanistic aspects of this disease. The
objective of this study was to 1) validate and evaluate
the reproducibility of quantitative magnetization
transfer (qMT), chemical exchange saturation transfer (CEST)
and fat imaging at 7T for assessing diabetic kidney
disease and 2) determine the potential of these
quantitative MRI approaches to distinguish moderate and
advanced DN. The long-term goal is to understand the
development and progression of fibrosis and lipid and
glucose deposition in accelerated diabetic kidney
disease.
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