Abstract #4106
Intra-individual crossover comparison of dose of gadoxetic acid for liver MRI: Parameter optimization and quantitative relaxometry in normal volunteers
Utaroh Motosugi 1,2 , Peter Bannas 1,3 , Diego Hernando 1 , Mahdi Salmani Rahimi 4,5 , James H. Holmes 6 , and Scott B. Reeder 1,7
1
Radiology, University of Wisconsin, Madison,
Wisconsin, United States,
2
Radiology,
University of Yamanashi, Chuo-shi, Yamanashi, Japan,
3
Radiology,
University Hospital Hamburg-Eppendorf, Humburg, Germany,
4
Biomedical
Engineering, University of Wisconsin, Madison,
Wisconsin, United States,
5
Radiology,
Stanford University, Stanford, Calfornia, United States,
6
5Global
MR Applications and Workflow, GE Healthcare, Madison,
Wisconsin, United States,
7
Medical
Physics, University of Wisconsin, Madison, Wisconsin,
United States
Gadoxetic acid is a hepatobiliary contrast agent with
important clinical applications. However, the approved
dose (0.025mmol/kg) is 1/4 that of traditional MR
contrast agents, that may result in insufficient contrast
especially for dynamic phase imaging. For this reason,
many institutions have adopted the use of higher doses
as a clinical standard. This motivated a systematic
evaluation of higher dosing of gadoxetic acid with
relaxometry. In this study, we show that 0.05mmol/kg
gadoxetic acid leads to significantly higher SNR and CNR
performance than 0.025mmol/kg. Further, a 10-minute
delay may be feasible for hepatobiliary-phase imaging
when using 0.05mmol/kg of gadoxetic acid.
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