Abstract #4097
Correlation of diffusion weighted imaging and apparent diffusion coefficient values of pancreatic ductal adenocarcinoma (PDAC) with clinicopathological features and overall survival.
John J Hermans 1 , Deniece Riviere 1 , Marnix Maas 1 , Monica Van Zanten 2 , Tanya Bisseling 3 , Martin Gotthardt 1 , and Kees Van Laarhoven 4
1
Radiology and Nuclear Medicine, Radboud
University Medical Center, Nijmegen, Gelderland,
Netherlands,
2
Pathology,
Radboud University Medical Center, Nijmegen, Gelderland,
Netherlands,
3
Gastroenterology
and Hepatology, Radboud University Medical Center,
Nijmegen, Gelderland, Netherlands,
4
Surgery,
Radboud University Medical Center, Nijmegen, Gelderland,
Netherlands
Retrospective analysis of 3T DWI-MRI was performed in 42
patients with a potentially resectable pancreatic
tumour. Whole mount slices of the tumor were obtained
from 10 resection specimens and graded according to
Adsay, who uses a major and minor pattern of glandular
differentiation, in analogy to Gleason for prostate
adenocarcinomas. There was no significant correlation
between mean ADC-values of PDAC, DWI-patterns, tumour
stage, grade (Klppel), size, presence of metastases or
OS. There was no significant correlation between Adsays
tumour grade and tumour stage or size. However, we found
a nearly significant correlation between Adsays tumour
grade and mean ADC (p=0,063).
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