Abstract #4094
Diffusion Tensor Imaging (DTI) in Liver Fibrosis with Minimal Confounding Effect of Hepatic Steatosis
Yunjung Lee 1 and Hyeonjin Kim 1,2
1
Radiology, Seoul National University
Hospital, Seoul, Korea,
2
Biomedical
Sciences, Seoul National University, Seoul, Korea
Given the potential confounding effect of fat on
apparent diffusion coefficient (ADC) in the liver in
diffusion MRI, we have assessed diffusion tensor imaging
(DTI) in liver fibrosis with minimal effect of fat on
ADC and fractional anisotropy (FA) at 9.4T by employing
a suitable animal model. Our results demonstrate that at
b=0 and 500 s/mm2, FA may be more sensitive to
mild-to-moderate liver fibrosis than ADC. In addition to
ADC as demonstrated elsewhere, FA may also be sensitive
to hepatic fat content, and therefore need to be
carefully interpreted in the presence of fatty liver.
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