Abstract #4061
Simultaneous T2 mapping in Near-Field Subcutaneous Fat Layer and PRFS Temperature Mapping in the Target Region using Fast Interleaved Sequences to Monitor MR-HIFU Sonication
Jochen Keupp 1 , Steffen Weiss 1 , Jaakko Tolo 2 , Holger Gruell 3,4 , and Edwin Heijman 3
1
Philips Research, Hamburg, Germany,
2
Philips
Healthcare, Helsinki, Finland,
3
Philips
Research, Eindhoven, Netherlands,
4
Eindhoven
University of Technology, Eindhoven, Netherlands
MR guided high-intensity focused ultrasound (MR-HIFU) is
establishing as a new treatment option for various
diseases that elegantly combines two non-invasive
technologies. Near-field ultrasound heating of the skin
and heat accumulation in the subcutaneous fat layer can
become problematic due to the low thermal conductivity
of fat. Currently, temperature mapping based on the
proton resonance frequency shift (PRFS) is applied
during clinical MR-HIFU treatment. However, reliable
PRFS temperature maps can only be acquired in
non-adipose tissue, while fat tissue requires different
temperature mapping techniques like e.g. based on
T2-mapping. Simultaneous temperature monitoring would be
desirable in separate FOVs, like the adipose far field
and non-adipose tumor regions. We here propose to use an
acquisition technology which quickly interleaves a PRFS
(gradient-echo) and a T2 (dual spin-echo) sequence on
the level of individual repetitions with microsecond
latency. Feasibility was demonstrated in a model setup
using ablation conditions on a clinical MR-HIFU system.
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