Abstract #4047
Investigating the utility of diffusion-weighted imaging (DWI) for monitoring treatment efficacy during MR guided High Intensity Focused Ultrasound (MRgHIFU) therapy in bone applications
Sharon L Giles 1 , Jessica M Winfield 2 , Ian Rivens 3 , David J Collins 2 , Gail R ter Haar 3 , and Nandita M deSouza 2
1
MRI Unit, Royal Marsden Hospital, Sutton,
Surrey, United Kingdom,
2
CRUK
Cancer Imaging Centre, The Institute of Cancer Research,
Sutton, Surrey, United Kingdom,
3
Therapeutic
Ultrasound, The Institute of Cancer Research, Sutton,
Surrey, United Kingdom
This study assesses the utility of DWI for detecting
tissue changes during MRgHIFU by evaluating
repeatability of ADC measurements and ADC changes after
sonication in n=7 lamb legs. Measurements were made in
soft tissues immediately adjacent to bone. Imaging
appearances were macroscopically compared with dissected
tissues. The coefficient of variation for repeat ADC
measurements was 1.0% and the degree of ADC change
increased with increasing power of sonications. A 20%
sustained increase in ADC produced visible lesions on
dissection, unapparent on T1- or T2-W imaging, making
DWI a potential tool for monitoring damage during
MRgHIFU in bone applications.
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