Abstract #4039
Non-invasive Assessment of Fibrosis and Inflammation in the whole kidney of CKD patients by Diffusion-Weighted Imaging with Readout-Segmented EPI
Iris Friedli 1 , Lindsey Alexandra Crowe 1 , Lena Berchtold 2 , Solange Moll 3 , Karine Hadaya 4 , Thomas De Perrot 1 , Pierre-Yves Martin 4 , Sophie De Seigneux 4 , and Jean-Paul Valle 1
1
Division of Radiology, Faculty of Medicine,
Geneva University Hospital, University of Geneva,
Geneva, Switzerland,
2
Division
of Internal Medicine, Faculty of Medicine, Geneva
University Hospital, University of Geneva, Geneva,
Switzerland,
3
Division
of Pathology, Faculty of Medicine, Geneva University
Hospital, University of Geneva, Geneva, Switzerland,
4
Division
of Nephrology, Faculty of Medicine, Geneva University
Hospital, University of Geneva, Geneva, Switzerland
Whole kidney fibrosis and inflammation was
non-invasively assessed with readout-segmented
diffusion-weighted imaging in CKD patients. An internal
validation study was performed using biopsy as a gold
standard. A ΔADC, defined as the difference of mean ADC
in the renal cortex and medulla improves fibrosis
evaluation by comparison to ADC alone in renal
transplant patients. Strong correlation was found
comparing ΔADC (R2=0.70, p<0.001) to the fibrosis. A
negative ΔADC was found in all patients with more than
40% of fibrosis suggesting the use of this index as
predictor for renal fibrosis as confirmed by the results
of the internal validation.
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