Abstract #4032
Gradient Echo Signal Decays in Gynecological Cancers Require a Gaussian Augmentation of the Mono-Exponential (GAME) Model: Preliminary Evaluation Post External Beam Radiation Therapy at 3T
Pelin Aksit Ciris 1,2 , Robert V. Mulkern 2,3 , Mukund Balasubramanian 2,3 , Antonio L. Damato 2,4 , Ravi T. Seethamraju 5 , Janice Fairhurst 1 , Ferenc A. Jolesz 1,2 , Clare M. Tempany-Afdhal 1,2 , Ehud Schmidt 1,2 , and Akila N. Viswanathan 2,4
1
Brigham and Women's Hospital, Boston, MA,
United States,
2
Harvard
Medical School, Boston, MA, United States,
3
Boston
Children's Hospital, Boston, MA, United States,
4
Dana-Farber
Cancer Institute, Boston, MA, United States,
5
Siemens
Healthcare, MA, United States
Tumor hypoxia increases treatment resistance and
metastatic potential. MRI attempts to detect hypoxia in
cervical cancer via R2* using multiple-gradient-echo
(GRE) signals with a standard Mono-Exponential (ME)
decay model were reported. We have evaluated this in
gynecologic cancers post External-Beam-Radiation-Therapy
(EBRT), and report that proper characterization of GRE
signals requires a Gaussian Augmentation of the
Mono-Exponential (GAME) decay model. GAME improves
characterization significantly (p<0.05) in 25% of all
tumor regions, and highly significantly (p<0.005) in 15%
of all tumor regions, which improves the potential for
finding biomarkers of e.g. oxygenation status, with
potential to improve targeting of radiation treatment.
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