Abstract #4028
Preclinical Magnetic Resonance Fingerprinting: Taking Advantage of Inherent Resistance to Motion Artifacts
Ying Gao 1 , Yong Chen 2 , Dan Ma 1 , Yun Jiang 1 , Katherine M. Dell 3 , Mitchell L. Drumm 3,4 , Mark A. Griswold 1,2 , Chris A. Flask 1,2 , and Lan Lu 2,5
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States,
2
Radiology,
Case Western Reserve University, Cleveland, Ohio, United
States,
3
Pediatrics,
Case Western Reserve University, Cleveland, Ohio, United
States,
4
Genetics,
Case Western Reserve University, Cleveland, Ohio, United
States,
5
Urology,
Case Western Reserve University, Cleveland, Ohio, United
States
Conventional MRI methods are highly susceptible to
motion artifacts, especially for preclinical body
imaging applications. We have implemented an MRF-FISP
acquisition on a high field preclinical MRI scanner to
simultaneously obtain
in
vivo
T
1
,
T
2
, and proton density maps for both healthy
and polycystic kidneys in mice and rats. Initial results
show that our preclinical MRF technique can provide
reasonable estimates of relaxation times and proton
density and is sensitive to known pathology. Most
importantly, these results confirm that the MRF
technique is inherently resistant to respiratory motion
artifacts which is a key advantage for body imaging
applications.
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