Abstract #3992
Bronchodilatation Effect on Alveolar Oxygen Partial Pressure and Gas Exchange Rate of Asthma Patients: First Results of Clinical Study
Maxim Terekhov 1 , Ursula Wolf 2 , Klaus K Gast 2 , Christian Hoffmann 2 , Sergei Karpuk 3 , Christian Mrozek 3 , Christoph Dueber 2 , and Laura Maria Schreiber 1
1
Radiology Department, Section of Medical
Physics, Johannes Gutenberg University Medical Center
Mainz, Mainz, Germany,
2
Radiology
Department, Johannes Gutenberg University Medical Center
Mainz, Mainz, Germany,
3
Institute
of Physics, Johannes Gutenberg University, Mainz,
Germany
In the present paper the intermediate results of open
clinical study on HP-3He-MRI measurements performed in
bronchial asthma patients are presented. The particular
aim was to investigate the effect of bronchodilatation
on the alveolar pO2 measured with 3He-MRI, and to
correlate the variation with the pulmonary function
tests (PFT). For the 50% of patient data analyzed up to
now we confirmed tentatively the increase of aPO2 after
BDL on about 5%. The median value of oxygen consumption
rate appears to be unchanged after BDL. However, the
heterogeneity of variation over the patients increases
by at least 50%.
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