Abstract #3985
Numerical Simulations of Xenon Diffusive Exchange in Human Lung Tissue and Capillaries using Geometrical Models Based on Histology Sections
Neil James Stewart 1 , Juan Parra-Robles 1 , and Jim Michael Wild 1
1
Academic Unit of Radiology, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom
Finite-element simulations of xenon diffusive exchange
NMR in the lungs were performed using: realistic 2D
geometries derived from human lung histology; and 3D
uniform cylindrical capillary models. Simulated
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MR signal dynamics from the cylinder models agreed well
with previous
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chemical shift saturation recovery (CSSR) MR data. The
non-uniform distribution of tissue thicknesses in the
histology sections considerably altered the shape of the
predicted
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signal dynamics. Artificial thickening of alveolar septa
caused increased diffusion-limitation of gas-exchange as
expected from MR measurements. These findings have
implications for future design of
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MR experiments and modelling of lung microstructure.
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