Abstract #3983
Second-Order Texture Analysis of Hyperpolarized 3 He MRI - Beyond the Ventilation Defect
Damien Pike 1,2 , Dante Capaldi 1,2 , Sarah Ashley Mattonen 2 , Fumin Guo 1,3 , Aaron Ward 2 , David McCormack 4 , and Grace Parraga 1,2
1
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
2
Department
of Medical Biophysics, The University of Western
Ontario, London, Ontario, Canada,
3
Graduate
Program in Biomedical Engineering, The University of
Western Ontario, London, Ontario, Canada,
4
Division
of Respirology, Department of Medicine, The University
of Western Ontario, London, Ontario, Canada
Current methods for evaluating pulmonary ventilation
heterogeneity from MRI are focused on quantifying
ventilation defects although this measurement does not
reflect ventilation patchiness or regional heterogeneity
on smaller-volume or length scales. Hence, our objective
was to develop a second-order texture analysis algorithm
to quantify and characterize
3
He
ventilation heterogeneity in healthy never-smokers and
participants with respiratory disease. Preliminary
results in a training dataset showed that
3
He
MRI texture measurements correlated with spirometry
(FEV1/FVC),
3
He
VDP and Vencov in healthy never-smokers.
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