Abstract #3981
What can multiple b-value 3 He MRI tell us about lung micro-structure in healthy elderly never-smokers?
Gregory Paulin 1,2 , Alexei Ouriadov 1,2 , Khadija Sheikh 1,2 , David G McCormack 3 , and Grace Parraga 1,2
1
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
2
Department
of Medical Biophysics, The University of Western
Ontario, London, Ontario, Canada,
3
Division
of Respirology, Department of Medicine, The University
of Western Ontario, London, Ontario, Canada
Diffusion-weighted noble gas pulmonary MRI provides in
vivo images with contrast uniquely sensitive to
molecular displacement at cellular and sub-cellular
length scales. We estimated the external airway radius
and internal airway radius of alveoli to evaluate
potential differences in acinar duct morphometries in
healthy older never-smokers using a multi-slice 2D
gradient echo diffusion-weighted sequence. Preliminary
results show that MRI measurements of lung morphometry
in older never-smokers were elevated compared to
previous results reported in younger never-smokers.
These findings are compatible with senile emphysematous
changes to healthy lung parenchyma that accompanies
aging.
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