Abstract #3973
Evaluation of a novel whole lung 3D dynamic OE-MRI protocol in healthy subjects
Jose L Ulloa 1,2 , Alexandra R Morgan 1,2 , and Geoff JM Parker 1,2
1
Bioxydyn Ltd, Manchester, United Kingdom,
2
Centre
for Imaging Sciences, University of Manchester,
Manchester, United Kingdom
Dynamic oxygen-enhanced MRI (dOEMRI) provides imaging
biomarkers of regional lung ventilation and perfusion.
However, time sampling constraints have limited it to
single slice imaging. In this work, we evaluate a novel
quantitative whole lung 3D dOEMRI protocol based on a
standard single-shot 3D MPRAGE sequence. Sequence
parameters were optimised to maximise contrast in the
lung when switching from air to O
2
. The
protocol enables the capture of the whole lung volume
within a breathing cycle. Six healthy volunteers were
scanned twice, one week apart. The protocol shows
reproducible T1 measurements and allows characterisation
of dynamic ΔpO
2
.
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