Abstract #3956
Relationship between Visual Functional Connectivity and Duration of Blindness Depends on Onset of Visual Deprivation
Matthew C. Murphy 1 , Amy C. Nau 1 , Christopher Fisher 1 , Seong-Gi Kim 2,3 , Joel S. Schuman 1,4 , and Kevin C. Chan 1,4
1
Department of Ophthalmology, University of
Pittsburgh, Pittsburgh, PA, United States,
2
Departments
of Biological Sciences and Global Biomedical
Engineering, Sungkyunkwan University, Suwon, Korea,
3
Department
of Radiology, University of Pittsburgh, Pittsburgh, PA,
United States,
4
Department
of Bioengineering, University of Pittsburgh, Pittsburgh,
PA, United States
Visual deprivation is known to induce plasticity of the
visual system, which can be observed through alterations
in functional connectivity (FC). How these FC changes
accrue over time and how this relationship between FC
and duration of blindness differs between early and late
acquired blindness are unknown. In this work, we modeled
the effects of prior visual experience on visual FC in
blind subjects. The results suggest that alterations in
FC due to visual deprivation progress over time, however
the direction of this progression in congenitally blind
subjects is opposite to that in subjects with acquired
blindness.
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