Abstract #3934
Stability of tissue model parameters: Using the full analytical solution or the asymptotic approximation?
Sebastian Domsch 1 , Sebastian Weingrtner 1 , Jascha Zapp 1 , and Lothar R. Schad 1
1
Computer Assisted Clinical Medicine,
Heidelberg University, Mannheim, Baden-Wrttemberg,
Germany
The oxygen extraction fraction is of great clinical
interest providing a biomarker for brain tissue
viability and a parameter for the evaluation of diseases
such as tumor, stroke, and Alzheimers disease. The
analytical tissue model in the static dephasing regime
has facilitated promising in-vivo results mapping
hemodynamic parameters such as the OEF and the venous
blood volume fraction separately using MRI. This work
shows a comparison between the fit results using the
full analytical model and the more frequently used
asymptotic approximation in terms of accuracy and
precision based on Monte-Carlo simulations and
robustness in-vivo.
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