Abstract #3928
Improved detection of olfactory fMRI BOLD signal with through-plane phase precompensated spectral-spatial pulses
Christopher Thomas Sica 1 , Prasanna Karunanayaka 1 , Jeff Vesek 2 , Jianli Wang 1 , and Qing X Yang 1,3
1
Radiology, Penn State College of Medicine,
Hershey, PA, United States,
2
Molecular
Biology, Penn State College of Medicine, Hershey, PA,
United States,
3
Neurosurgery, Penn State
College of Medicine, Hershey, PA, United States
Susceptibility field gradients (SFG) cause undesired
through-plane dephasing and associated signal loss near
the sinus region, especially for fMRI scans with
substantial echo times. One recently developed approach
to mitigating the signal loss is the use of
spectral-spatial pulses that apply a frequency dependent
through-plane phase precompensation. This pre-phasing of
the magnetization will cancel out the dephasing due to
SFGs, leading to signal recovery at TE. We evaluated
and demonstrated the ability of spectral-spatial pulses
to improve detection of BOLD activation in the olfactory
regions near the base of the brain.
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