Abstract #3915
Whole brain BOLD functional MRI in the presence of metallic orthodontic braces
Yuankui Wu 1,2 , David Woods 3 , Moshe T. Stern 4 , Nicholas I.S. Blair 5 , Raag D. Airan 6 , James J. Pekar 1,7 , Peter C. M. van Zijl 1,7 , and Jun Hua 1,7
1
Neurosection, Div. of MRI Research, Dept. of
Radiology, Johns Hopkins University School of Medicine,
Baltimore, Maryland, United States,
2
Department
of Medical Imaging, Nanfang Hospital, Southern Medical
University, Guangzhou, Guangdong, China,
3
Department
of Orthodontics and Pediatric Dentistry, University of
Maryland School of Dentistry, Baltimore, Maryland,
United States,
4
Department
of Orthodontics and Pediatric Dentistry, University of
Maryland, Baltimore, Maryland, United States,
5
Department
of Biomedical Engineering, Johns Hopkins University,
Baltimore, Maryland, United States,
6
Div.
of Neuroradiology, Dept. of Radiology, Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States,
7
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States
Gradient echo (GRE) EPI BOLD sequences are sensitive to
susceptibility effects and render signal dropouts in the
brain in the presence of metallic objects such as dental
braces. This impedes the application of fMRI especially
for studies involving teenage participants. T2prep-BOLD
sequences use a readout similar to MPRAGE, which is much
less sensitive to susceptibility effects. Here, we
compare GRE-EPI and T2prep-BOLD in whole brain resting
state fMRI scans in the presence of metallic orthodontic
braces. T2prep-BOLD scans showed minimal dropout in the
whole brain, and greater temporal SNR and BOLD
sensitivity in the EPI dropout regions than GRE-EPI
BOLD.
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