Abstract #3891
Intravoxel incoherent motion MRI may reveal microvascular variation of fibroglandular tissues in breast cancer
Jing Yuan 1 , Gladys G. Lo 2 , Oi Lei Wong 1 , Helen H.L. Chan 2 , Abby Y. Ding 1 , Ting Ting Wong 3 , and Polly S.Y. Cheung 3
1
Medical Physics and Research Department,
Hong Kong Sanatorium & Hospital, Happy Valley, Hong
Kong, China,
2
Department
of Diagnostic & Interventional Radiology, Hong Kong
Sanatorium & Hospital, Happy Valley, Hong Kong, China,
3
Breast
Care Center, Hong Kong Sanatorium & Hospital, Happy
Valley, Hong Kong, China
This study aims to investigate the micro-vascularity of
fibroglandular tissues (FGTs) in breast cancer (BC)
using intravoxel incoherent motion (IVIM) MRI. 21
histology-confirmed patients received IVIM-MRI at 3T.
True diffusion D, pseudo-diffusion D*, pseudo-diffusion
fraction f and ADC in ipsilateral and contralateral
breast FGTs were compared. Results show that FGT D* and
f in the ipsilateral tumor-bearing breast were higher
than those in the contralateral breast (D*:
24.969.3710
-3
mm
2
/s v.s.
19.989.3710
-3
mm
2
/s; f:
0.1230.034 v.s. 0.1090.030), with D* being
significant (p=0.033). FGT microvascular variation
revealed by IVIM-MRI may potentially be used for breast
cancer risk assessment, characterization and/or
prognosis
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