Abstract #3868
Spontaneous R2* Fluctuations for Non-Invasive Detection of Cyclic Hypoxia in Head and Neck Squamous Cell Carcinoma Xenografts
Rafal Panek 1 , Lauren C.J. Baker 2 , Liam Welsh 1 , Carol Box 2 , Suzanne A. Eccles 2 , Kate L. Newbold 1 , Kevin J. Harrington 1 , Maria A. Schmidt 1 , Martin O. Leach 1 , and Simon P. Robinson 2
1
Royal Marsden NHS FT and Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
2
Institute
of Cancer Research, Sutton, Surrey, United Kingdom
The importance of acutely hypoxic tumour cells,
resulting from intermittent tumour blood flow, on tumour
progression and radioresistance is recognised. The
potential of continuous intrinsic susceptibility MRI
measurements of tumour R
2
* to non-invasively
detect acute, cyclic hypoxia through changes in the oxy/deoxyhaemoglobin
ratio has been previously demonstrated. In this study we
have tested the feasibility of measuring spontaneous
fluctuations in tumour R
2
* to identify
regions with varying erythrocyte or plasma channels flow
in head and neck squamous cell carcinoma xenografts on a
clinical 3T platform. Additionally, hyperoxia-induced
R
2
*
and tissue histology were used to spatially confirm
hypoxic and perfused tumour regions.
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