Abstract #3855
Clinical Application of 3D High Resolution Multi-shot Diffusion-Weighted MRI in Prostate Cancer Patients undergoing Active Surveillance Protocol for Low-Risk Prostate Cancer
Christopher Nguyen 1,2 , Ali-Reza Sharif-Afshar 3 , Zhaoyang Fan 1 , Sidney Wilson 2 , Xiaoming Bi 4 , Lucas Payor 5 , Rola Saouaf 5 , Hyung Kim 3 , and Debiao Li 1,2
1
Biomedical Imaging Research Institute,
Cedars Sinai Medical Center, Los Angeles, CA, United
States,
2
Bioengineering,
University of California Los Angeles, Los Angeles, CA,
United States,
3
Surgery
/ Urology, Cedars-Sinai Medical Center, Los Angeles, CA,
United States,
4
Siemens
Healthcare, Los Angeles, CA, United States,
5
Radiology,
Cedars-Sinai Medical Center, Los Angeles, CA, United
States
In a small group of prostate cancer patients undergoing
active surveillance (AS-PC) patients, a recently
developed novel 3D diffusion-prepared multi-shot
balanced steady-state free precession technique
demonstrated improved suspicious low risk prostate
cancer lesion detection compared with single-shot
diffusion-weighted echo planar imaging (SS-DW-EPI). We
conducted a follow-up study in a significantly larger
cohort to further investigate the clinical impact of the
proposed technique. The proposed technique continued to
yield significantly better lesion detection of
biopsy-confirmed lesions compared with SS-DW-EPI. By
improving lesion detection, the proposed technique may
allow DW MRI to potentially monitor low-risk prostate
cancer lesions in AS-PC.
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