Abstract #3844
The ADC ratio of tumour to normal prostate as a robust method for quantifying diffusion weighted imaging of the prostate
Tristan Barrett 1 , Andrew N Priest 2 , Edward M Lawrence 1 , Debra Goldman 3 , Vincent J. Gnanapragasam 4 , Evis Sala 5 , and Ferdia A. Gallagher 1
1
Radiology, Cambridge University Hospitals,
Cambridge, Cambridgeshire, United Kingdom,
2
Cambridge
University Hospitals, Cambridge, Cambridgeshire, United
Kingdom,
3
Department
of Epidemiology and Biostatistics, Memorial Sloan
Kettering Cancer Center, New York, New York, United
States,
4
Urology,
Cambridge University Hospitals, Cambridge,
Cambridgeshire, United Kingdom,
5
Radiology,
Memorial Sloan Kettering Cancer Center, New York, New
York, United States
We investigate the ability of apparent diffusion
coefficient (ADC) ratios of tumour-to-normal prostate to
improve concordance between ADC values obtained from
different b-value combinations within the same patients.
Whole gland histopathology was used as a gold-standard.
Concordance correlation between different b-value
combinations was higher for ADC ratios compared to
absolute ADC values. ADC maps incorporating a b-0 value
demonstrated greater variability for both ratio and
absolute values, likely relating to pseudo-perfusion
effects. ADC ratios showed stronger inverse
relationships to Gleason grade than absolute values. ADC
ratios may therefore provide a more robust means of
assessing restricted diffusion in the prostate.
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