Abstract #3833
Statistical Assessment of Diffusion Weighted Signal Decay in Breast Cancer Tumors at 3T: Mono-exponential or Bi-exponential?
Jing Yuan 1 , Gladys G. Lo 2 , Oi Lei Wong 1 , Helen H.L. Chan 2 , Abby Y. Ding 1 , Ting Ting Wong 3 , and Polly S.Y. Cheung 3
1
Medical Physics and Research Department,
Hong Kong Sanatorium & Hospital, Happy Valley, Hong
Kong, China,
2
Department
of Diagnostic & Interventional Radiology, Hong Kong
Sanatorium & Hospital, Happy Valley, Hong Kong, China,
3
Breast
Care Center, Hong Kong Sanatorium & Hospital, Happy
Valley, Hong Kong, China
This study prompts to rigorously assess and
statistically compare DWI signal fitting in malignant
breast tumor by using mono-exponential ADC model and
bi-exponential intra-voxel incoherent motion (IVIM)
model via F-test. ROI-averaged analysis showed that more
tumors (n=24) were significantly better fitted by
bi-exponential than by mono-exponential models (n=14).
In contrast, voxel-wise analysis showed that more voxels
presented mono-exponential DWI signal decay in tumors.
With clinically achievable SNR, IVIM-MRI should be
helpful for ROI-averaged DWI fitting to characterize
tumor microvascularity while voxel-wise IVIM values
should be carefully interpreted with caution due to
possible inaccuracy and high uncertainty.
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