Abstract #3831
Prediction of neoadjuvant therapy response using multiparametric MRI at 3T
Lenka Minarikova 1 , Wolfgang Bogner 1 , Katja Pinker-Domenig 2 , Thomas Helbich 2 , Siegfried Trattnig 1 , and Stephan Gruber 1
1
MRCE, Department of Biomedical Imaging and
Image-guided Therapy, Medical University of Vienna,
Vienna, Austria,
2
Division
of Molecular and Gender Imaging, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria
Response prediction during neoadjuvant chemotherapy
(NAC) should have an important role in therapy plan
modifications, which would result in increase of
disease-free survival. In our study we measured breast
cancer patients in three time points: before, during and
after the NAC, using DCE and DWI MRI at 3T to look for
potentially better response prediction markers. Our
results suggest that multiparametric data measured
during the ongoing NAC correspond better with
histopathologic outcome than data measured after NAC
completion. However, mean ADC values alone didnt show
any outcome prediction ability.
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