Abstract #3828
Evaluation of Benign and High-Risk, Nonmalignant Breast Lesions, assessed as False-Positive at Contrast-Enhanced (CE) MRI using DW imaging and CE MR Imaging Features
Sunitha B Thakur 1 , Jung Hun Oh 2 , Milans Soledad 2 , Harini Veeraraghavan 2 , Merlin M Gnanasigamani 2 , Elizabeth J Sutton 2 , Joseph O Deasy 2 , and Elizabeth A Morris 2
1
Memorial Sloan Kettering Cancer Center, New
York, NY, United States,
2
Memorial
Sloan Kettering Cancer Center, NY, United States
Lesions that are classified high-risk typically
require complete surgical excision; a procedure that is
expensive and can cause anxiety and morbidity.
Therefore, the ability to distinguish between lesions,
especially to differentiate the high-risk benign group
from other benign lesions would be extremely helpful in
a clinical setting. We conducted this study in order to
evaluate the imaging characteristics of non-malignant
lesions and classify them using (i) apparent diffusion
coefficient (ADC) values, (ii) morphological and (iii)
texture-based image features derived from contrast
enhanced magnetic resonance imaging. We used 3.0T MRI
data from 111 women and found that lower ADC values
appear to correlate with high-risk breast lesions. This
study is useful because it probes the concept of
distinguishing not just between malignant and benign
lesions but goes further to classify benign lesions into
subgroups that could be treated differently at the
clinical level.
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