Abstract #3822
MRI-based measurement of tissue O 2
Scott C. Beeman 1 , Ying-Bo Shui 2 , John A. Engelbach 1 , Joseph J.H. Ackerman 1,3 , and Joel R. Garbow 1
1
Radiology, Washington University, Saint
Louis, Missouri, United States,
2
Ophthalmology,
Washington University, Saint Louis, Missouri, United
States,
3
Chemistry, Washington University,
Saint Louis, Missouri, United States
Diatomic oxygen (O
2
), as found dissolved in
tissue, is a critical component in aerobic metabolism
and a fundamental determinant of physiological
functional status. Reliable, non-invasive methods for
measuring tissue O
2
content
are lacking. We quantify the relaxivity of brain-tissue
O
2
and,
subsequently, changes in brain-tissue oxygenation in
healthy brain, radiation lesions, and tumor lesions. By
quantifying the change in brain tissue oxygenation with
MRI, we were able to differentiate tumor lesions from
radiation necrosis lesions two pathologies that have
proven extremely difficult to differentiate with common
radiological techniques.
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