Abstract #3811
Biomarkers of Aggressive Breast Cancer Revealed by Combining Magnetic Resonance Spectroscopic Imaging and Mass Spectrometric Imaging
Lu Jiang 1 , Kamila Chughtai 2 , Tiffany Greenwood 1 , Zaver M. Bhujwalla 1 , Venu Raman 1 , Gert Eijkel 2 , Ron Heeren 2 , and Kristine Glunde 1
1
Department of Radiology, Johns Hopkins
University School of Medic, BALTIMORE, MD, United
States,
2
FOM-Institute
AMOLF, Amsterdam, Netherlands
The total choline (tCho) signal in magnetic resonance
spectroscopic imaging (MRSI) of tumors is a potential
biomarker of breast cancer aggressiveness and can be
visualized in vivo by H1 MRSI tCho maps. Mass
spectrometry imaging (MSI) of histologic tumor sections
is able to detect thousands of biomolecules, including
tryptic peptides from on-tissue digested proteins, from
the tissue surface. We have investigated differentially
regulated proteins in high- versus low-tCho regions in a
human breast cancer model by combining in vivo MRSI with
ex vivo MSI, which identified specific protein species
that are spatially correlated with tCho.
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