Abstract #3799
Evaluation of the Errors in the Measured Dynamic Contrast Enhancement with TWIST View Sharing Using a Novel Simulation Strategy
Yuan Le 1 , Marcel Dominik Nickel 2 , Randall Kroeker 3 , Christian Geppert 2 , Bruce Spottiswoode 3 , and Chen Lin 1
1
Radiology and Imaging Science, Indiana
University School of Medicine, Indianapolis, IN, United
States,
2
Siemens
Healthcare, Erlangen, Bavaria, Germany,
3
Siemens
Medical Solutions, NC, United States
In order to investigate the representation of complex
tumors when using modern, view sharing MRI sequences
such as TWIST, dynamic contrast-enhanced TWIST raw data
were generated from static background and a fractal
tumor phantom raw data scaled with an enhancement model.
Our results show that, for typical spatial resolution in
clinical breast DCE-MRI, TWIST parameters of pA=20%-25%
and pB=33% provided an enhancement measurement with
lowest RMS error. The measured shape irregularity of the
tumor changed in a less predictable way, however, which
should be taken into consideration in the texture
analysis of the images.
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