Abstract #3661
T1 corrected fat quantification using a dual flip angle acquisition and joint fit reconstruction
Xiaoke Wang 1 , Diego Hernando 2 , and Scott B. Reeder 2,3
1
Biomedical Engineering, University of
Wisconsin, Madison, Wisconsin, United States,
2
Radiology,
University of Wisconsin, Madison, Wisconsin, United
States,
3
Medical Physics, University of
Wisconsin, Madison, Wisconsin, United States
The estimation of PDFF by CSE imaging may be biased by
T1 relaxation. T1 related bias can be minimized by using
a small flip angle (SFA) approach. SFA results in
reduced SNR and residual bias. T1 bias can also be
corrected using a dual flip angle method (standard DFA),
which redundantly estimates R2* and B0 twice. In this
study, we propose a joint fitting of T1, B0, R2* and
PDFF based on dual-flip-angle acquisition (joint DFA).
Joint DFA slightly reduced noise in R2* and PDFF
estimates compared with standard DFA as shown by
Cramer-Rao lower bound and Monte Carlo simulation.
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