Abstract #3584
The dynamics of cerebrovascular reactivity shown with transfer function analysis
James Duffin 1,2 , Olivia Sobczyk 3 , David J Mikulis 3,4 , and Joseph A Fisher 1,2
1
Department of Physiology, University of
Toronto, Toronto, Ontario, Canada,
2
Department
of Anaesthesia and Pain Management, University Health
Network, Toronto, Ontario, Canada,
3
Institute
of Medical Sciences, University of Toronto, Toronto,
Ontario, Canada,
4
Joint
Department of Medical Imaging and the Functional
Neuroimaging Laboratory, University Health Network,
Toronto, Ontario, Canada
The cerebrovascular reactivity (CVR) to a stimulus
assesses the health of the cerebovasculature. When
measured with MRI, the resulting CVR values for each
voxel can be displayed using a color scale mapped onto
the corresponding anatomical scan to generate CVR maps
showing the distribution of the vascular responses.
However, such CVR maps estimate only the magnitude, and
do not indicate the time course of the response; whether
rapid or slow. Transfer function analysis provides not
only the magnitude of the response but also the phase,
an indicator of the response dynamics, as well as a
measure of the fidelity with which the response follows
the stimulus.
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