Abstract #3582
Characterization of carotid plaque composition using ex-vivo Magnetic Resonance Imaging at 7T and histopathology
Rosario Lopez-Gonzalez 1 , Sin Yee Foo 2 , William M Holmes 3 , William Stewart 4 , Keith Muir 5 , Barrie Condon 6 , George Welch 7 , and Kirsten Forbes 8
1
Clinical Physics and Bioengineering, NHS,
Glasgow, Glasgow, United Kingdom,
2
School
of Medicine, University of Glasgow, Glasgow, United
Kingdom,
3
GEMRIC,
Institute of Neuroscience and Psychology, Glasgow,
United Kingdom,
4
Neuropathology,
NHS, Glasgow, United Kingdom,
5
Division
of Clinical Neurosciences, University of Glasgow,
Glasgow, United Kingdom,
6
NHS,
Glasgow, United Kingdom,
7
Vascular
Surgery, NHS, Glasgow, United Kingdom,
8
Institute
of Neurological Sciences, NHS, Glasgow, United Kingdom
This study aims to evaluate the ability to identify all
major carotid plaque components using ex-vivo 7T MRI and
correlation with histology. Surgical excision of
atherosclerotic carotid plaque (carotid endarterectomy,
CEA), based on the extent of luminal narrowing, reduces
risk of subsequent stroke. However, 70% of patients with
severe stenosis remain stroke-free over the next 5 years
with medical therapy alone. Outcomes from CEA could be
improved by targeting treatment at high-risk subgroups.
Atherosclerotic plaque morphology and plaque composition
may identify unstable or vulnerable plaque that defines
higher risk.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
