Abstract #3578
A study on brain-behaviour functional relations in areas affected due to ischemic stroke using diffusion MRI
J. Mitra 1 , P. Bourgeat 1 , J. Fripp 1 , O. Salvado 1 , B. Campbell 2 , S. Palmer 3 , P. Goodin 3 , A. Connelly 3,4 , S. Rose 1 , L. Carey 3,4 , and the START Program Team 5
1
Australian e-Health & Research Centre, CSIRO
Digital Productivity Flagship, Herston, QLD, Australia,
2
Department
of Radiology, The Melbourne Brain Centre at the Royal
Melbourne Hospital, VIC, Australia,
3
The
Florey Institute of Neuroscience and Mental Health,
Parkville, VIC, Australia,
4
La
Trobe University, Bundoora, VIC, Australia,
5
http://www.START.csiro.au,
VIC, Australia
Cerebral white matter is especially vulnerable to
hypoxic-ischemic injury, resulting in white matter
lesions. Knowledge of how brain networks are interrupted
is currently limited, but critical to better
understanding the nature of the clinical deficit and
stroke recovery. We used diffusion-weighted MRI and
probabilistic tractography to identify the common neural
pathways affected in stroke patients, with a view of
predicting cognitive and functional deficits associated
with the affected areas. Our hypothesis is that loss in
connectivity in these common regions will correlate with
the clinical measurements of cognition, sensorimotor
function and disability.
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