Abstract #3571
Task-dependent neurovascular uncoupling in Moyamoya disease
Erin L Mazerolle 1 , Yuhan Ma 2 , David Sinclair 2 , and G Bruce Pike 1
1
University of Calgary, Calgary, Alberta,
Canada,
2
McGill
University, Montreal, Quebec, Canada
We investigated task-related hemodynamics in moyamoya
disease (MMD). Patients with MMD exhibit abnormal
cerebrovascular reactivity in anterior brain regions,
which we predicted would be associated with
neurovascular uncoupling. We compared BOLD fMRI
activation maps among tasks with varying extents of
associated vascular demands. For tasks associated with
extensive vascular demands, we found atypically low
activation in MMD-affected brain regions, reflective of
neurovascular uncoupling. This activation could be
partially or completely recovered when the total extent
of the tasks vascular demands was reduced. Thus, the
potential effects of neurovascular uncoupling must be
considered in patients with cerebrovascular disease.
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