Abstract #3563
Lateralization of Glx and GABA metabolic changes in anterior cingulate for Ultra High Risk Schizophrenia patients.
Petr Menschikov 1 , Natalia Semenova 1,2 , Maxim Ublinskii 3 , Dmitry Kupriyanov 4 , Irina Lebedeva 5 , Maria Omelchenko 5 , and Tolibjon Akhadov 3
1
N.N. Semenov Institute of Chemical Physics
of the Russian Academy of Sciences, Moscow, Russian
Federation,
2
N.M.
Emanuel Institute of Biochemical Physics of the Russian
Academy of Sciences, Moscow, Russian Federation,
3
Children's
Clinical and Research Institute of Emergency Surgery and
Trauma, Moscow, Russian Federation,
4
Philips
Healthcare Russia, Moscow, Russian Federation,
5
National
Mental Health Research Centre of the Russian Academy of
Medical Sciences, Moscow, Russian Federation
It was reported previously that GLX is reduced in
anterior cingulate (AC) for chronic schizophrenia
patients medicated with antipsychotic drugs. Reduction
of GLX in right hemisphere in our study reflects changes
in the metabolic system as a consequence of the illness
itself, without influence of treatment with
antipsychotics or age changes. We assume also that left
AC GABA reduction observed in our study is typical for
schizophrenia development - previously reported
unchanged GABA in AC of young chronic medicated patients
could be associated with an effect of antipsychotic
medication.
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