Abstract #3547
Abnormal Bioenergetics in the 1st episode Schizophrenia, Preliminary Studied by the Magnetization Transfer 31P-MRS
Fei Du 1 , Cagri Yuksel 1 , Scott Lukas 1 , Bruce Cohen 1 , and Dost Ongur 1
1
McLean Hospital, Harvard Medical School,
Belmont, MA, United States
In vivo probes of cerebral bioenergetics have the
capacity to provide crucial information to characterize
the exact abnormalities and delineate their
relationships with pathophysiology and symptom
presentation of schizophrenia. Using novel 31P-MT-MRS
and both 1st-episode and chronic patients, our findings
indicate schizophrenia may be characterized by an
initial active phase of excessive glutamatergic
neurotransmission and bioenergetic activity, which then
progressively becomes downregulated and result in
decreased intracellular pH in the chronic condition. Our
findings provide insight into the progression of
schizophrenia and highlight the value of using cerebral
activity and bioenergetic metabolism as new biomarkers
of the pathophysiology of schizophrenia.
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