Abstract #3531
Cerebral Metabolite Differences and Correlations in Short-Term Binge Ethanol-Exposed Rats: A Study of Ex Vivo Proton Nuclear Magnetic Resonance Spectroscopy at 11.7-T
Do-Wan Lee 1,2 and Bo-Young Choe 1
1
Department of Biomedical Engineering, and
Research Institute of Biomedical Engineering, The
Catholic University of Korea College of Medicine, Seoul,
Seoul, Korea,
2
Asan
Institute for Life Sciences, Asan Medical Center, Seoul,
Korea
The first goal of this study was to determine the
influence of dose-dependent short-term binge ethanol
(SBE) exposure on cerebral neurochemical differences and
responses among controls (CNTL) and low-(SBE-1.5) and
high-(SBE-2.5) dose ethanol-exposed rats. The second
goal was to determine correlations between
metabolite-metabolite levels
(pairs-of-metabolite-levels) using individual metabolite
data from hippocampal region of SBE-exposed rats. From
our results and previous studies, altered various
metabolite signals may indicate that SBE-exposure leads
to various biological changes, such as changes in rate
of GABA and glucose synthesis, impairment of an
antioxidant defense system, abnormal ATP function in
energy-metabolism, and dysfunctions of anaerobic
respiration.
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