Abstract #3520
Investigation of the Confounding Effects of Vasculature and Metabolism on Computational Anatomy Studies
Christine Lucas Tardif 1 , Christopher John Steele 1 , Pierre-Louis Bazin 1 , Arno Villringer 1 , and Claudine Jolle Gauthier 1,2
1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Saxony, Germany,
2
Department
of Physics, Concordia University, Montreal, Quebec,
Canada
T1 maps were acquired under normal, hypercapnic
(increased CO2) and hyperoxic (increased O2) breathing
conditions to investigate the confounding effects of
dissolved oxygen, blood flow and blood volume on
computational anatomy studies. We show a decrease in T1
during hypercapnia and hyperoxia, as well as an increase
in cortical thickness during hypercapnia. These biases
should be taken into account when interpreting MR-based
structural plasticity studies of ageing and learning,
for instance.
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