Abstract #3491
Prenatal Inflammation and Stress Impairs Neurodevelopmental Trajectories As Measured By T2-Relaxometry
J. Keiko McCreary 1 , L. Sorina Truica 1 , Ashlee Matkin 2 , Albert R. Cross 3 , David M. Olson 4 , and Gerlinde A. S. Metz 1
1
Neuroscience, University of Lethbridge,
Lethbridge, Alberta, Canada,
2
Faculty
of Medicine, University of Alberta, Alberta, Canada,
3
Departments
of Physics and Neuroscience, University of Lethbridge,
Alberta, Canada,
4
Departments
of Obstetrics & Gynecology, Pediatrics and Physiology,
University of Alberta, Alberta, Canada
This study investigated the effects of maternal
inflammation and stress on offspring neurodevelopmental
trajectories. We used in vivo magnetic resonance imaging
(MRI) to analyze maps of transverse relaxation times
(T2) to provide a quantitative measure of brain tissue
changes in an animal model of maternal stress and
inflammation induced by IL-1B treatment. The MRI
findings, confirmed by histology, indicate that exposure
to IL-1B and stress during gestation causes an increase
in neuronal density in cortical layers I-III. This could
reflect disturbed neuronal pruning during brain
development, which represents a prominent
neuropathological finding in human neurodevelopmental
disorders.
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