Abstract #3488
A Novel Method of G-ratio Measurement in White Matter with Validation of Monte Carlo Simulation
Mu Lin 1 , Hongjian He 1 , Congyu Liao 1 , and Jianhui Zhong 1
1
Center for Brain Imaging Science and
Technology, Zhejiang University, China, Hangzhou,
Zhejiang, China
The g-ratio is equal to the ratio between axon diameter
and fiber diameter (axon plus myelin sheath). Previous
studies have shown that g-ratio can be a potential
biomarker for white matter that is sensitive to the
process of demyelination and remyelination after
disease, as well as sex differences in the brain
development of adolescences. We propose a noninvasive
way to estimate g-ratio. To validate the accuracies of
our method, we simulate the effect of multi-component T2
and diffusion on g-ratio with a three-compartment Monte
Carlo model.
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