Abstract #3475
White matter structural development from mid-fetal stage to normal time of birth
Austin Ouyang 1 , Qiaowen Yu 2 , Virendra Mishra 1 , Lina Chalak 3 , Tina Jeon 1 , Jonathan M Chia 4 , Muraleedharan Sivarajan 3 , Nancy Rollins 5 , Shuwei Liu 2 , and Hao Huang 1,6
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, TX, United
States,
2
Research
Center for Sectional and Imaging Anatomy, Shandong
University School of Medicine, Shandong, China,
3
Department
of Pediatrics, University of Texas Southwestern Medical
Center, Dallas, TX, United States,
4
Philips
Healthcare, Cleveland, Ohio, United States,
5
Department
of Radiology, Children's Medical Center, Dallas, TX,
United States,
6
Department
of Radiology, University of Texas Southwestern Medical
Center, TX, United States
Structural characterization of white matter (WM)
maturational processes from mid-fetal stage to normal
time of birth is critical for understanding not only the
normal development of WM tracts but also the clinical
implications associated with abnormal WM development
such as PVL. With high resolution DTI of early
developing brains at 20wg, 35wg and 40wg, establishment
of population-averaged age-specific template, WM
skeleton extraction and DTI-based tractography of
individual WM tracts, we aimed to understand the
spatiotemporally heterogeneous microstructural and
macrostructural development of individual WM tracts,
including myelination, axonal packing and volume growth,
from mid-fetal stage to normal time of birth.
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