Abstract #3473
Population-averaged age-specific DTI templates of preterm human brain at 33, 36 and 39 gestational weeks
Virendra Mishra 1 , Kenichi Oishi 2 , Hang Li 1,3 , Tina Jeon 1 , Minhui Ouyang 1 , Lina Chalak 4 , Jonathan M Chia 5 , Yun Peng 3 , Nancy Rollins 6 , Susumu Mori 2 , and Hao Huang 1,7
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Department
of Radiology and Radiological Science, The Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States,
3
Department
of Radiology, Beijing Children's Hospital Affiliated to
Capital Medical University, Beijing, China,
4
Department
of Pediatrics, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,
5
Philips
Medical Systems, Dallas, Texas, United States,
6
Department
of Radiology, Children's Medical Center at Dallas,
Dallas, Texas, United States,
7
Department
of Radiology, University of Texas Southwestern Medical
Center, Dallas, Texas, United States
From 30 weeks of gestation (wg) to normal time of birth
(40wg), human brain maturation results in dramatic
structural alterations. These dramatic structural
differences make it difficult and presumably inaccurate
to adopt a single atlas for MRI and DTI acquired from
preterm brains in the age range of 30wg to 40wg. In this
study, we aimed to establish population-averaged
age-specific DTI templates of preterm human brains at
33wg, 36wg and 39wg. We further evaluated these
age-specific DTI templates by showing statistically
significant and inhomogeneous local expansions with
transformations of younger preterm brains to the
templates of older brains.
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