Abstract #3468
Comparison between the single-compartment and two-compartment parameters derived from diffusion kurtosis imaging in assessing the axon growth
Xianjun Li 1,2 , Jie Gao 1 , Qinli Sun 1 , Yanyan Li 1 , Huan Li 1 , Mingxi Wan 2 , and Jian Yang 1,2
1
Radiology Department of the First Affiliated
Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi,
China,
2
Department
of Biomedical Engineering, School of Life Science and
Technology, Xi'an Jiaotong University, Xi'an, Shaanxi,
China
The purpose of this study was to compare the
performances of the single-compartment and the
two-compartment parameters of diffusion kurtosis imaging
(DKI) in assessing the axon growth. In this study, 22
healthy term neonates (11 males and 11 females) and 22
healthy adults (11 males and 11 females) were examined.
Fourteen regions of interests (ROIs) were selected by
using the atlas-based analysis. Inter-group differences
of the regional values were tested by using the Wilcoxon
Signed Rank Test. This DKI study investigated changes of
the intra-axonal and extra-axonal diffusivities, as well
as the single-compartment fractional anisotropy (FA)
through the comparison between the neonates and adults.
FA increased by 105.16 % in the adults, compared with
that in neonates. The relative decrease of extra-axonal
radial diffusivity was 24.88 %. Few significant changes
of extra-axonal axial diffusivity were found.
Intra-axonal diffusivity demonstrated largest relative
changes in adults (261.21 %). This result was in
agreement with the fact that the myelinated axon was
more than twice the axon caliber of the unmyelinated
axon. In conclusion, the intra-axonal diffusivity was a
sensitive biomarker for the assessment of the axon
growth. White matter model for DKI provided more detail
information for investigating the white matter
development.
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