Abstract #3457
Regional differences in CVR developmental patterns in healthy children
Jackie Leung 1 , Junseok Kim 2 , Przemyslaw Kosinski 2 , and Andrea Kassner 1,3
1
The Hospital for Sick Children, Toronto,
Ontario, Canada,
2
Institute
of Medical Science, University of Toronto, Toronto,
Ontario, Canada,
3
Medical
Imaging, University of Toronto, Toronto, Ontario, Canada
Cerebrovascular reactivity (CVR) measures the capacity
of cerebral blood vessels to dilate in response to a
vasoactive stimulus. Global CVR has recently been shown
to change significantly during childhood and
adolescence, but very little is currently known about
regional changes of CVR with age. This information can
refine our understanding of cerebral physiology in
children. The purpose of this study was to determine
whether the developmental trajectories of CVR in
children are region specific. Our findings suggest that
the evolution of CVR is regionally dependent, differing
in both rate of change and age of peak CVR.
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