Abstract #3451
Childhood Obesity is Associated with Lower Grey Matter Volume in Children
Xiawei Ou 1,2 , Aline Andres 3,4 , R.T. Pivik 3,4 , Mario Cleves 3,4 , and Thomas Badger 3,4
1
Arkansas Children's Hospital Research
Institute, Arkansas Children's Nutrition Center, Little
Rock, AR, United States,
2
Radiology
and Pediatrics, University of Arkansas for Medical
Sciences, Little Rock, AR, United States,
3
Arkansas
Children's Nutrition Center, Little Rock, AR, United
States,
4
University
of Arkansas for Medical Sciences, AR, United States
Recent studies have reported associations between morbid
obesity and changes in brain structure and/or function.
In this study, we used voxel-based morphometry (VBM) to
evaluate brain grey matter development in healthy
school-aged children who are either normal weight or
obese. Our results showed that obese (otherwise healthy)
children had significantly lower regional grey matter
volume in widespread brain regions compared to normal
weight children. Whether there is a cause-effect
relationship between childhood obesity and changes in
brain development will need further investigation.
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