Abstract #3449
Maternal Obesity Negatively Affects Offsprings Brain White Matter Development
Xiawei Ou 1,2 , Aline Andres 3,4 , Keshari M Thakali 3 , Kartik Shankar 3,4 , and Thomas Badger 3,4
1
Arkansas Children's Hospital Research
Institute, Arkansas Children's Nutrition Center, Little
Rock, AR, United States,
2
Radiology
and Pediatircs, University of Arkansas for Medical
Sciences, Little Rock, AR, United States,
3
Arkansas
Children's Nutrition Center, Little Rock, AR, United
States,
4
University
of Arkansas for Medical Sciences, AR, United States
While strong evidence links maternal adiposity with
increased risk for childhood obesity and related health
concerns, less is known about potential effects of
maternal body composition on fetal CNS development. In
this study, we employed DTI to examine brain structure
in 2-week-old term infants born from normal weight and
obese mothers. Our results demonstrated that infants
from obese mothers have lower white matter development
(as indicated by lower FA values) than those born of
normal weight mothers. White matter development in
newborn infants negatively correlated with maternal
adiposity. The mechanisms underlying these effects and
their consequences are under investigation.
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